Mike Tyson vs. Jake Paul odds, prediction, props, date, rules: Nov. 15 fight card picks by best boxing expert

Jake Paul vs. Mike Tyson could be one of the most anticipated sporting events of the year. The bout between the social media influencer-turned-boxer and the former heavyweight champion is scheduled for Friday, Nov. 15, a sanctioned fight that will go on each competitor’s record. The 27-year-old Paul (11-10, 7 KO) last stepped into the ring in a July TKO of former UFC fighter Mike Perry. The 58-year-old Tyson (50-6, 44 KO), hasn’t fought professionally since a TKO defeat to Kevin McBride in 2005. 

The latest Jake Paul vs. Mike Tyson odds list Paul as the -330 favorite (risk $330 to win $100) to win, with Tyson a +250 underdog, with the over/under for total rounds at 5.5, with the Over priced at -150. The broadcast starts at 8 p.m. ET. Before making any Mike Tyson vs. Jake Paul picks, make sure you see the boxing predictions and betting advice from SportsLine combat expert Brandon Wise.  

Wise, who is the combat sports editor for CBS Sports, is an experienced boxing and mixed martial arts analyst who has consistently provided winning selections for SportsLine members. For the past four years, he has hit numerous boxing selections in big-time matchups.

For example, in March, Wise called a win in Round 1 for Paul (+200) against Ryan Bourland and also advised SportsLine members to take the Under 1.5 rounds (+120). Both bets connected when Paul scored a knockout towards the end of the first round. Anyone who has followed Wise’s combat sports picks has already seen massive returns.

Now, with the Paul vs. Tyson fight card approaching, Wise has studied the matchup from every angle and released confident picks for the fight. You can only see his picks and analysis at SportsLine. 

Mike Tyson vs. Jake Paul predictions  

Wise has analyzed the Jake Paul vs. Mike Tyson bout and is leaning Over 5.5 rounds at -150 odds. Wise notes the improvement in Paul’s ring work since making his pro debut in 2020, including his ability to dodge heavy blows that could end a fight early. Of Paul, Wise says he “has figured out how to control action with his jab. He’s done well to stay at distance and away from much of the danger on the inside.”

Avoiding danger has allowed Paul to never get knocked out in his career, while the heavier 14-ounce gloves should prevent lots of damage being inflicted on either fighter. Heavier gloves both offer more protection and slow down punching power, thus reducing the chances of a knockout. As for Tyson, he showed he still has some stamina well into his 50s as he lasted all eight rounds in his 2020 bout with Roy Jones Jr. Add in that six of Paul’s last eight matches have also gone over 5.5 rounds, and Wise comfortably backs the Over (-150) in this fight’s distance. See who to pick here. 

How to make Jake Paul vs. Mike Tyson picks

Wise has also locked in a confident money line pick and a method-of-victory prop bet that could pay out big. He’s only sharing his picks and analysis at SportsLine.

Who wins Mike Tyson vs. Jake Paul on November 15, and which Paul vs. Tyson props should you be all over? Visit SportsLine now to see Brandon Wise’s best bets for the July 20 bout, all from the CBS combat sports specialist who just called Paul’s first-round win in March, and find out.