Kansas State vs. Arizona prediction, odds, line, time: 2025 college football Week 3 picks from proven model

The Kansas State Wildcats hit the road to take on the Arizona Wildcats in a Big 12 matchup on Friday night. K-State is 1-2 overall, and 0-1 in conference play. KSU is looking to bounce back from a stunning 24-21 upset loss to Army in its last outing. Arizona is 2-0 on the season, with both wins coming in dominant fashion. Brent Brennan’s team has outscored its two opponents this season 88-9, including a 48-9 win over Weber State on Sept. 6. Kansas State leads the all-time series 6-3. Arizona is 2-0 against the spread this season, while KSU is 1-2 ATS. 

Kickoff from Arizona Stadium in Tucson, Ariz., is scheduled for 9 p.m. ET. KSU is a 1.5-point favorite in the latest Arizona vs. Kansas State odds, while the over/under for total points scored is 54.5. Before making any Kansas State vs. Arizona picks, be sure to check out the college football predictions from the SportsLine Projection Model. 

New users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and is a profitable 31-19 combined on money-line and over/under college football picks since the beginning of 2024. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Arizona vs. Kansas State and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Here are the FBS college football odds and trends for Arizona vs. Kansas State:

Why Arizona can cover

Arizona has been dominant in its two wins this season. The Wildcats haven’t exactly faced stiff competition, but they have notched statement wins in both games. In its season opener, Arizona beat Hawaii 40-6, then followed that up by beating Weber State 48-3 last weekend. 

Arizona is led by junior quarterback Noah Fifita. The 5-foot-10, 186-pound quarterback is in his third full season as the program’s starter, and is looking to rebound from an inconsistent 2024 season where he completed 60.5% of his passes for 2,958 yards with 18 touchdowns and 12 interceptions. For his career, Fifita has totaled 6,742 passing yards, 50 touchdown passes, and 18 interceptions. See which team to back at SportsLine. 

Why Kansas State can cover

Kansas State has faced a challenging start to the 2025 season, entering Week 3 with a 1–2 record. After a narrow 24–21 loss to Iowa State in the College Football Classic in Dublin, the Wildcats secured a 38–35 victory over North Dakota in their home opener. However, they suffered another 24–21 upset loss to Army in a closely contested game on Fort Riley Day, marked by a late interception that sealed their fate.

KSU is paced by veteran quarterback Avery Johnson. The 6-foot-3 dual-threat quarterback has demonstrated significant growth over his college career, amassing 3,954 passing yards and 36 touchdowns across 24 games. In the 2025 season, he has completed 64 of 98 passes for 763 yards, six touchdowns, and one interception, maintaining a passer rating of 148.9. See which team to back at SportsLine.

New users can also check out the latest BetMGM promo code, offering new users up to $1,500 in bonus bets if their first bet loses:

How to make Kansas State vs. Arizona picks

SportsLine’s model is leaning Over on the point total, projecting 60 combined points. It also says one side of the spread hits in more than 50% of simulations. You can only get the model’s pick and full analysis at SportsLine. 

So who wins Kansas State vs. Arizona, and which side of the spread cashes in more than 50% of simulations? Visit SportsLine now to see which side of the Kansas State vs. Arizona spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.