Browns vs. 49ers: Where to watch NFL Week 13, betting odds, score prediction, SGP picks, sportsbook promos

Highly notable rookie quarterback Shedeur Sanders will make his second start for the Cleveland Browns when they host the San Francisco 49ers in Week 13 of the NFL season. Sanders got the ball for Cleveland (3-8) in Week 12 and defeated the Las Vegas Raiders on the road, and defensive superstar Myles Garrett continued his march towards challenging the single-season sacks record. San Francisco (8-4) beat the Carolina Panthers on Monday Night Football. 

Kickoff from Huntington Bank Field is set for 1 p.m. ET on CBS and Paramount+. The 49ers are 5.5-point favorites, according to the latest Browns vs. 49ers odds. The over/under for total points scored is 35.5, down seven from the opening line. The 49ers are -257 money line favorites (risk $257 to win $100), while the Browns are +209 underdogs. Before making any Browns vs. 49ers picks, make sure you check out the NFL picks from the SportsLine Projection Model. Be sure to watch this game on CBS and Paramount+, where new users can get a free one-week trial. Sign up here. 

Click here to bet Browns vs. 49ers at BetMGM Sportsbook, where new users get either $150 in bonus bets if your first bet wins or up to $1,500 in bonus bets if your first bet loses:

Where to bet on Browns vs. 49ers

Where to watch Browns vs. 49ers on Sunday

When: Sunday, Nov. 30
Time: 1 p.m. ET
TV: CBS
Stream: Paramount+ 
Follow along: CBS Sports App

Browns vs. 49ers betting preview

Odds: 49ers -5.5, over/under 35.5

Cleveland is 3-8 outright but has managed to go 5-6 ATS and is 6-5 to the Over despite its excellent defense. The Niners are 7-5 ATS and 7-5 to the Over. Both teams have gone Over in three of their last four games, and both have covered their last two games.

Click here to bet Browns vs. 49ers at FanDuel Sportsbook, where new users get $150 in bonus bets if their first bet of at least $5 wins:

• Browns +5.5
• Quinshon Judkins anytime touchdown scorer
• Harold Fannin Jr. Over 35.5 receiving yards

Final odds: +525 at DraftKings (wager $100 to win $525)

Model’s Browns vs. 49ers score prediction, picks

San Francisco wins in 55% of the model’s simulations, but Cleveland offers more money line betting value at +198 odds. The Browns cover in 58% of the simulations, while the Over hits in a strong 64% of the sims. 

Browns vs. 49ers score prediction: 49ers 23, Browns 21

Want more Week 13 NFL picks?

You’ve seen the model’s best bets for Cleveland Browns vs. San Francisco 49ers. Now, get against the spread, total and money-line picks for every Week 13 NFL game here, all from the model that’s simulated every game 10,000 times.