Michigan vs. Northwestern prediction, odds: Week 12 college football picks by proven model

The 21st-ranked Michigan Wolverines will look to keep their Big Ten Conference championship hopes alive when they take on the Northwestern Wildcats in a key conference matchup on Saturday. Michigan is coming off a 21-16 win over Purdue on Nov. 1, while Northwestern dropped a 38-17 decision at USC last Friday. The Wolverines (7-2, 5-1 Big Ten), who are tied for third in the conference with USC and Oregon, are just 2-2 on the road this season. The Wildcats (5-4, 3-3 Big Ten), who are tied for ninth in the league, are 4-1 on their home field in 2025.

Kickoff from Wrigley Field in Chicago is at noon ET. Michigan leads the all-time series 60-15-2, including eight in a row. The Wolverines are 10.5-point favorites in the latest Michigan vs. Northwestern odds, while the over/under for total points scored is 41.5 via SportsLine consensus. Before making any Northwestern vs. Michigan picks, check out the college football predictions from the SportsLine Projection Model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has set its sights on Michigan vs. Northwestern. You can visit SportsLine now to see the picks. Here are the FBS college football odds and trends for Northwestern vs. Michigan:

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How to make Michigan vs. Northwestern picks

SportsLine’s model is going over on the total (41.5 points). Northwestern has gone over in each of the last two games, and the over has hit in four of the past eight meetings between the teams. Michigan quarterback Bryce Underwood is expected to throw for more than one touchdown in the simulations, while Wolverines running back Jordan Marshall is expected to surpass 125 yards rushing in the model’s simulations. 

So who wins Michigan vs. Northwestern, and which side of the spread is the better value? Visit SportsLine now to see which side of the Michigan vs. Northwestern spread to jump on, all from the advanced model that finished up over $2,000 on its FBS college football picks since its inception, and find out.