NFL DFS: Optimizer releases Week 2, 2025 daily fantasy football lineups, picks, advice for DraftKings, FanDuel

The NFL Week 2 Sunday slate features several compelling matchups, including a Super Bowl rematch between the Philadelphia Eagles and Kansas City Chiefs at Arrowhead Stadium. Other notable games include the Chicago Bears facing the Detroit Lions, and the Atlanta Falcons visiting the Minnesota Vikings on Sunday Night Football. With such a loaded slate, daily Fantasy football players will need to dive deeper into NFL DFS player pool to find values for NFL DFS lineups. Should you target big name players like Patrick Mahomes, Jahmyr Gibbs, Josh Allen, Derrick Henry or Saquon Barkley when making NFL DFS picks or building out you Week 2 NFL DFS strategy? 

Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS Lineup Optimizer.

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.

Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 2 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Top NFL Week 2 DFS picks for Sunday

One of the Optimizer’s top DFS value picks for Sunday is Bengals quarterback Joe Burrow ($6,600 on DraftKings and $8,000 on FanDuel). In the Bengals’ 17–16 victory over the Cleveland Browns in Week 1 of the 2025 NFL season, Burrow completed 14 of 23 passes for 113 yards and one touchdown, leading the team to its first Week 1 win in four years. Despite his modest numbers last week, Burrow remains one of the most explosive fantasy quarterbacks in the league.

The 2019 Heisman Trophy winner has what is arguably the top wide receiver duo in the NFL at his disposal in Ja’Marr Chase and Tee Higgins. The Bengals are facing a Jaguars defense on Sunday that looked solid, but vulnerable, in Week 1. The Optimizer has Burrow projected to finish with well over 20 points on both DraftKings and FanDuel on Sunday against the Jaguars in a game that has the highest total (49) of the weekend. See who else to pick here.

The Optimizer’s NFL DFS strategy also includes rostering Giants wide receiver Malik Nabers ($7,100 on DraftKings and $7,700 on FanDuel), who has an over/under of 6.5 receptions. Nabers, the Giants’ 2024 first-round pick, has quickly established himself as a dynamic and explosive presence in the NFL, combining elite acceleration and top-end speed with exceptional ball-tracking skills, making him a constant deep threat.

Nabers’ 2024 rookie season was record-setting, with 109 receptions, 1,204 yards, and seven touchdowns, earning him a Pro Bowl selection and setting the Giants’ franchise record for most receptions in a season. Known for his quick, flexible route-running and ability to generate yards after the catch, Nabers is poised to be an elite fantasy wide receiver option all season. You can see the rest of the Optimizer’s NFL DFS picks here.

How to build Sunday Week 2 NFL DFS lineups

The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the Optimizer’s NFL DFS picks, at SportsLine. 

So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS Optimizer that simulates every game 10,000 times, and find out.