NFL DFS: Optimizer reveals Week 11, 2025 daily Fantasy football picks for DraftKings, FanDuel

Eleven more NFL games are set for Sunday afternoon either in the 1 p.m. ET or 4:05/4:25 p.m. ET window, and those matchups comprise the main slate for NFL DFS sites like FanDuel and DraftKings. One of the early kickoffs — Bengals vs. Steelers– has the highest over/under (49.5) for the week, so that game should be a focus for NFL daily Fantasy players with big names like Josh Allen, Ja’Marr Chase and James Cook in action. Other big names expected to be playing on the main slate include Justin Herbert, Bijan Robinson and Christian McCaffrey. Lamar Jackson (knee) missed practice on Wednesday, but returned Thursday and Friday and carries no injury designation, clearing him to be part of the player pool as well. 

How should they factor into your NFL DFS picks this week, and who are the sleepers in the NFL DFS player pool that can help differentiate your lineups? Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine’s advanced NFL DFS lineup optimizer.

New users can also target the latest Underdog promo code, where they can pick at Underdog and get $100 in site credits after making a $5 wager:

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool.

Now, SportsLine’s NFL DFS Optimizer has turned its attention to Sunday’s 2025 NFL Week 11 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

New users can get $50 in Pick6 credits at DraftKings when they play $5.

Top NFL Week 11 DFS picks for Sunday

One of the optimizer’s top DFS value picks for Sunday is Los Angeles Chargers quarterback Justin Herbert at $6,300 on DraftKings and $8,200 on FanDuel. Playing in a more run-centric Jim Harbaugh offense limited his Fantasy production last year, but a rash of injuries at running back has Los Angeles throwing the ball more in 2025 with Ladd McConkey, Keenan Allen, Quentin Johnston and tight end Oronde Gadsden II all putting up big numbers. Herbert and the Chargers face the Jaguars, who have given up the second-most Fantasy points to opposing quarterbacks this season. See who else to pick here.

The optimizer’s NFL DFS strategy also includes building around Atlanta receiver Drake London at $8,400 on FanDuel and $7,400 on DraftKings. The fourth-year pro is pacing for career-best number across the board as he enters Week 11 with a 53-691-6 receiving line. He faces a tougher matchup against a Carolina defense that has been solid overall against the pass. London, however, dominated the Panthers in their second meeting last year, posting a massive 10-187-2 line, giving him huge upside at a value price on Sunday. You can see the rest of the optimizer’s NFL DFS picks here.

New users can also check out the latest FanDuel promo code and get $150 in bonus bets at FanDuel if your $5 bet wins. 

How to build Sunday Week 11 NFL DFS lineups

The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the optimizer’s NFL DFS picks, at SportsLine. 

So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and find out.