Self-learning AI shares NFL against the spread, over-under, money-line picks for every 2024 Week 1 game

It has been eight years since the Cowboys visited Cleveland, but 36 since the Browns defeated Dallas at home. That’s a drought the Dawg Pound will try to end during the Week 1 NFL schedule as Cleveland hosts Dallas. The Browns are 2.5-point home favorites in the NFL odds, one of three contests with Week 1 NFL spreads of under three points. The others both have the road team favored, thus making Cleveland the slightest home favorite, according to the Week 1 NFL betting odds. Other NFL matchups with NFL lines under a field goal include Texans vs. Colts (+2.5) and Vikings vs. Giants (+1.5).

Week 1 NFL score predictions are always the hardest to make since you don’t truly know how good a team is until you see them play, so many of the Week 1 NFL Vegas lines could end up looking way off in hindsight. Before you make any Week 1 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine’s AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 1, the AI PickBot has evaluated the NFL odds and provided NFL predictions for all 16 games. You can only see the AI predictions for the Week 1 NFL schedule here.

Top Week 1 NFL AI picks

After analyzing every game in Week 1, the AI PickBot says the Broncos cover as six-point underdogs against the Seahawks in a game that has earned an A-rated pick. The Seahawks have quietly fielded the NFL’s worst defense over the last two years as no team has allowed more total ypg (366.5) or rush ypg (144.3) over that span. Now, it has to face a Sean Payton-led offense, and no head coach in NFL history averages more team ppg (27.1) than Payton.

Broncos RB Javonte Williams is now a full year removed from his torn ACL, so he should be closer to his rookie year form when he led the NFL in broken tackles than the still-recovering player he was last year. He should find success versus Seattle, as should rookie QB Bo Nix, who set the FBS single-season record for completion percentage in 2023. Just six teams allowed a higher CMP% than the Seahawks last year, so it has issues defending both the run and the pass. With that, the AI PickBot predicts this game’s point differential to just be 1.52 points, and either direction allows the Broncos to cover as 6-point underdogs. See its other Week 1 football predictions and football picks at SportsLine.

How to make Week 1 NFL picks

In addition, the AI PickBot has generated eight more A-rated picks for Week 1. You need to see the AI PickBot’s analysis before making any Week 1 NFL bets. You can only see it at SportsLine.

Who wins and covers each Week 1 NFL game, and which A-rated picks should you be targeting?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.