Week 4 NFL odds, lines, betting picks, spreads: 2025 predictions: Computer model backs Chargers, Bears

The Week 4 NFL schedule sets up nicely for football fans with must-see games in each viewing window. Eagles vs. Buccaneers (+3.5, 44) at 1 p.m. ET features the only matchup of undefeated squads you can make Week 4 NFL predictions on. Then at 4:25 p.m. ET, a pair of two-time MVPs in Patrick Mahomes and Lamar Jackson will square off as the Chiefs host the Ravens. Baltimore is a 2.5-point road favorite, per the latest Week 4 NFL odds, despite Kansas City winning six of the last seven meetings between the two.

Then on Sunday Night Football, one of the fiercest rivalries takes center stage with Cowboys vs. Packers. Micah Parsons will return to Dallas for the first time since being dealt away, and his Packers are favored by 6.5 points on the road, per the Week 4 NFL spreads despite a shocking defeat to Cleveland last Sunday. In addition to these three contests, 10 others also have NFL spreads of a touchdown or less. All of the updated Week 4 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 4 NFL picks now. 

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, it has turned its attention to the latest Week 4 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick. 

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Top Week 4 NFL predictions

We can tell you one of the model’s strongest Week 4 NFL picks is that the Chargers (-6.5, 43.5) cover the spread at the Giants in a Sunday 1 p.m. ET kickoff. L.A. has started off 3-0, with all three wins coming within the division, while the Giants are winless. Dating back to last year, the Chargers have won six straight games which is the longest active win streak in the regular season. Justin Herbert leads the NFL with 860 passing yards and is looking like an MVP favorite, while the defense is also carrying its weight as no team has allowed fewer passing touchdowns than Los Angeles.

The Giants are coming off a Sunday night home loss to the Chiefs, dropping New York to 1-9 at home over the last two seasons as it prepares to host the Chargers. Jaxson Dart will make his first career start, but he doesn’t have much of a defense to lean on. The Giants defense ranks in the bottom 10 in points allowed, yards allowed, third down defense and redzone defense. The model has Los Angeles prevailing versus the spread over 50% of the time. See which other teams to pick here.

Another one of its Week 4 NFL predictions: The Bears (+1.5, 47.5) cover at Vegas in well over 50% of simulations. The Raiders looked listless in a defeat to Washington on Sunday, despite the Commanders being without Jayden Daniels. Vegas is simply being manhandled in the trenches as Geno Smith’s 12 times sacked are the second-most in the NFL, while prized rookie RB, Ashton Jeanty, is averaging just 3.1 yards per carry. Now Vegas has to face a Bears team which didn’t allow Caleb Williams to get sacked in Sunday’s win over Dallas, while the Chicago defense forced four turnovers.

The Raiders have covered in just three of their last nine home games, as they lost versus the spread at home in Week 2. The Bears have also defeated the Raiders the last two times these squads have played, including Chicago’s last trip to Las Vegas in 2021. In addition to Chicago covering, the model also says the Under hits almost 60% of the time. See which other teams to pick here.

How to make Week 4 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 4 NFL schedule and just revealed four teams that outright win over 70% of the time, potentially giving you a huge payday. You can only get every pick for every game at SportsLine.

So what Week 4 NFL picks can you make with confidence, and which four teams should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 4 NFL betting odds, lines, live spreads, scores

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