Packers vs. 49ers odds, line, spread: Sunday Night Football picks, predictions from model on 122-81 roll

Written by on September 26, 2021

The Green Bay Packers will visit the San Francisco 49ers in the NFL Week 3 Sunday Night Football matchup. After a putrid Week 1 performance against the New Orleans Saints, the Packers redeemed themselves on Monday Night Football by defeating the Detroit Lions, 35-17. The 49ers have won back-to-back games in fairly impressive fashion to start off the year 2-0. 

Kickoff from Levi Stadium is at 8:20 p.m. ET. San Francisco is a three-point favorite in the latest Packers vs. 49ers odds from Caesars Sportsbook, while the Over-Under is 50. Before locking in your 49ers vs. Packers picks, make sure you check out the NFL predictions and analysis from the proven SportsLine Projection Model

The model, which simulates every NFL game 10,000 times, is up almost $7,800 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 3 of the 2021 season on an incredible 122-81 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up. 

Now, the model has simulated Packers vs. 49ers 10,000 times and just revealed its NFL Week 3 picks and predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Packers vs. 49ers:

  • Packers vs. 49ers spread: Packers +3
  • Packers vs. 49ers over-under: 50 points 
  • Packers vs. 49ers money line: Green Bay +145, SF -170 
  • GB: Packers are 8-2 against the spread in their last 10 games in September  
  • SF: Over is 5-1 in 49ers’ last six games in Week 3 

Featured Game | San Francisco 49ers vs. Green Bay Packers

Why the Packers can cover

Green Bay bounced back in a big way on Monday night, defeating the Detroit Lions, 35-17. Aaron Rodgers looked like the superstar quarterback that he is under the bright lights of Monday Night Football. He was 22-of-27 for 255 yards and four touchdowns. 

Down 17-14 at the beginning of the third quarter, Rodgers uncorked a beautiful 50-yard throw down the right sideline to Davante Adams. He then followed up by throwing a 22-yard rocket over the middle of the field to Robert Tonyan that gave Green Bay a 21-17 lead. Rodgers and the Packers seemed to find their rhythm offensively, so look for it to continue on the road against San Francisco. 

Why the 49ers can cover

Deebo Samuel is off to a strong start to the season. Samuel currently leads the league in receiving yards with 282 yards on 15 receptions with one score. In the season-opener, Samuel torched the Lions’ secondary, reeling in nine catches for 182 yards. The 2019 second-round pick appears well on his way to establishing himself as one of the NFL’s elite wide receivers.

Samuel has caught four passes of 20 or more yards, which is tied for second in the league. The former South Carolina Gamecock is averaging a league-high 141 receiving yards a game with a whopping 18.8 yards per reception. Samuel has the quickness and agility to make defenders miss in open space and could give Green Bay’s secondary fits. 

How to make Packers vs 49ers picks 

SportsLine’s model is leaning over on the point total, projecting the teams to combine for 49.5 points. In fact, it says Green Bay’s Aaron Rodgers will throw for 230 yards and two touchdowns, while San Francisco quarterback Jimmy Garoppolo will throw for more than 200 yards with two touchdowns. The model also says one side of the spread has all the vakye. You can only see the model’s Green Bay vs. San Francisco picks at SportsLine.

So who wins 49ers vs. Packers on Sunday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the 49ers vs. Packers spread to jump on, all from the advanced model that is up over $7,900 on its NFL picks, and find out.

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